American immunologist James Allison won the Nobel Prize in Medicine for his research on cancer immunotherapy. For more than thirty years, he has faced the doubts of the medical community and the obstruction of big pharmaceutical groups alone in order to get new anti-cancer drugs on the market. His strong passion for medical science stems from the death of a loved one from cancer and his own experience with cancer several times. This film closely records Allison's journey to defeat cancer, interviews several medical leaders and anti-cancer fighters, and leads the audience to witness major medical achievements and gain insight into Allison's passion for life!