The prince Ashitaka, cursed with a deadly spell, leaves his homeland in search of a cure, only to become entangled in a fierce struggle between the forest gods and the people of a mining town. Along his journey, he encounters Princess San, a girl raised by the wolf gods, who is willing to go to war with humans to protect the forest. As tensions rise and bloodshed looms, can Ashitaka prevent a massacre and lift the curse upon him in this clash between nature and humanity?